Journal: Frontiers in Cellular Neuroscience
Article Title: Dichotomous Effects of Mu Opioid Receptor Activation on Striatal Low-Threshold Spike Interneurons
doi: 10.3389/fncel.2017.00385
Figure Lengend Snippet: Atropine but not mecamylamine abolished the depolarizing effects of DAMGO. (A) Application of DAMGO in the presence of a muscarinic receptor antagonist (atropine) produced a reversible hyperpolarization of an LTSI. This effect was reversed after washout. (B) Distribution of changes in the membrane potential induced by DAMGO in eight LTSIs in the presence of atropine. (C) Changes in the firing frequency induced by DAMGO in one spontaneously active LTSI in the presence of atropine. (D) Application of DAMGO in the presence of mecamylamine produced a reversible hyperpolarization of an LTSI. (E) Distribution of changes in the membrane potential induced by DAMGO in 10 LTSIs in the presence of mecamylamine. (F) Another LTSI was reversibly depolarized after DAMGO application in the presence of mecamylamine. This depolarization was associated with increased firing. (G) Distribution of changes in the firing frequency induced by DAMGO in six spontaneously active LTSIs in the presence of mecamylamine. DAMGO significantly increased firing frequency in one LTSI and significantly decreased firing frequency in five LTSIs.
Article Snippet: The proportion of depolarization caused by DAMGO in the presence of TTX (66.7%) was significantly larger than that observed in control solution (15.38%; p = 0.007; N-1 Chi-squared test for binomial distributions).
Techniques: Produced, Membrane